Why are Immunosuppressants so Important?
Immunosuppressants block the immune system's
normal reaction to reject transplanted tissue.
T cells, the principal immune system cells that
react against foreign tissues, are controlled
by a carefully determined combination of immunosuppressants.
The transplant recipient starts anti-rejection
medication immediately after transplant and must
take them for the life of the transplanted organ.
To prevent rejection, transplant recipients must
follow their drug regimen exactly as prescribed,
taking the right dosage at the right time. A constant
flow of medication in the bloodstream will help
prevent rejection of the new organ.
Effective antirejection therapy balances two
key elements: effectiveness and side effects.
The drugs have to be strong enough to suppress
the body's natural inclination to reject the transplanted
organ, while causing minimal side effects to the
patient. Because everyone reacts to medications
differently, each transplant recipient's drug
levels need to be carefully tailored.
Patients must return to the transplant clinic
to have their medication levels checked as often
as required. Transplant patients could experience
a rejection episode without even knowing it; that's
why it's important for transplant recipients to
stay in touch with their transplant coordinator
and keep their clinic appointments. Based on follow-up
test results, medication dosages may be adjusted.
Some tips on immunosuppressants for post-transplant
patients:
- Take your medication. Never skip a dose.
- Take your medications at the prescribed time.
- Understand when to take your drugs in relation
to food (whether to take before, during or after
your meals), because food can affect the absorption
of your medicines. Follow the guidelines your
doctor gives to you and be consistent about
when you take your medicine.
If you have additional questions about immunosuppressants,
call your transplant nurse or physician.
Reviewed by Robert
Grossman, MD
Last updated March 2004
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