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Comprehensive Care at Every Stage of Heart Failure
Transplantation for Diabetic Patients with Kidney Disease
Medical Indications for Liver Transplantation
Sleep and Gastroesophageal Reflux
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Current Issue: March/April 2008

Clinical Briefing: Comprehensive Care at Every Stage of Heart Failure
The Heart Failure and Transplantation Program at the Hospital of the University of Pennsylvania (HUP) has developed a multidisciplinary algorithm for heart failure management that reflects the chronic, progressive nature of the disease. Thus, the program provides a seamless continuum of care to address heart failure, its effects and comorbidities from its earliest stages onward.

Clinical Briefing: Transplantation for Diabetic Patients with Kidney Disease
Home to one of the oldest and most-established kidney transplant programs in the world, the Penn Transplant Institute is among the few transplant centers currently providing comprehensive care for diabetic patients with end-stage renal disease (ESRD). Diabetes is associated with a mortality rate that exceeds 50% within three years of dialysis initiation.

Medical Indications for Liver Transplantation
Despite great strides in surgical technique and operative technologies, a variety of challenging medical issues continue to confront centers specializing in liver transplantation. Chief among these are the management of active HCV infection prior to surgery, and the prevention of recurrent liver disease and graft rejection in the months following surgery.

Sleep and Gastroesophageal Reflux
Clinical studies and case reports have long defined the relationship between acid reflux and sleep disorders in patients with gastroesophageal reflux disease (GERD) as one of simple cause and effect. Recent studies suggest, however, that the association is much more complex.

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