A muscle biopsy is the removal of a small piece of muscle tissue for examination.

A muscle biopsy can usually be obtained while you are awake and the area being biopsied is numbed by local anesthesia. A needle biopsy may be adequate in children and adults with chronic conditions. In this procedure, a needle in inserted into the muscle. When the needle is removed, a small piece of tissue remains in the needle. The tissue is sent to a laboratory for examination.

More than one needle insertion may be needed to get a large enough sample.

Open biopsy involves a small cut through the skin and into the muscle, so that a piece of muscle tissue can be removed from the affected area.

A muscle that has recently been injured, such as by an EMG needle, or that is affected by pre-existing condition, such as nerve compression, is not a good choice for a biopsy.

No fasting or other special preparation is usually necessary.

During the biopsy, there is usually minimal or no discomfort. You may feel some pressure or "tugging" sensations.

The anesthetic may burn or sting when injected (before the area becomes numb). After the anesthetic wears off, the area may be sore for about a week.