A bone lesion biopsy is a test in which a piece of bone or bone marrow is removed for examination.

A bone lesion biopsy involves removal of a small piece of bone for examination. A special drill needle is usually used. A local anesthetic is given (to numb the area, the patient remains conscious), a small (about 1/8 inch) incision is made in the skin and the biopsy needle is pushed and twisted into the bone.

Once the sample is obtained, the needle is twisted out and the sample is sent for examination. Pressure is applied to the site. Once bleeding stops, the site is cleaned and covered with a bandage.

Bone biopsy may also be performed under general anesthesia for surgical excision (cutting out) of a piece of bone. Excision provides a larger specimen and may permit immediate surgical removal if examination indicates a malignant (cancerous) tumor.

You may be told not to drink or eat anything for several hours before the biopsy.

With a needle biopsy, you may feel moderate discomfort and pressure, even though a local anesthetic is used. You must remain still during the procedure.

After the biopsy, the area may be sore or tender for several days.