The synovial membrane is tissue that lines a joint. In this biopsy, a sample is taken of the joint lining.

The test may be done in your health care provider's office. The joint to be biopsied will be positioned so there is easy access. The joint will be injected with a local anesthetic.

Next, an instrument (trocar) used to force fluid from a cavity is inserted into the joint space. The biopsy needle is inserted through the trocar and twisted to cut out a tissue segment. The biopsy needle is removed and the trocar is removed. The biopsy site is cleansed and pressure and bandage are applied.

This procedure may also be performed in a hospital via arthroscopy.

Tell your health care provider if you have any drug allergies . Also make sure your health care provider knows which medications you are taking (including any herbal medicines and supplements), if you have bleeding problems, and if you are pregnant.

With the local anesthetic, you will feel a prick and a burning sensation. As the trocar is inserted, there will be some discomfort.