Serum globulin electrophoresis is a laboratory test that looks at proteins called globulins in the blood.

See also:

• Immunoelectrophoresis - serum
• Protein electrophoresis - serum

Blood is drawn from a vein, usually on the inside of the elbow or the back of the hand. The puncture site is cleaned with antiseptic. An elastic band is placed around the upper arm to apply pressure and restrict blood flow through the vein. This causes veins below the band to swell with blood.

A needle is inserted into the vein, and the blood is collected in an airtight vial or a syringe. During the procedure, the band is removed to restore blood flow. Once the blood has been collected, the needle is removed. The puncture site is covered to stop any bleeding.

For an infant or young child, the area is cleansed with antiseptic and punctured with a sharp needle or a lancet. The blood may be collected in a small glass tube (pipette), on a slide, onto a test strip, or into a small container. Cotton or a bandage may be applied to the puncture site if bleeding continues.

Electrophoresis is a laboratory technique. The fluid part of blood (serum) is placed on specially treated paper and exposed to an electric current. The proteins move on the paper (migrate) to form bands that show the amount of each protein fraction in relation to the other protein fractions.

Fast for 4 hours before the test. The health care provider may advise you to stop taking drugs that can interfere with the test. DO NOT stop taking any medications without first telling your health care provider.

When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging sensation. Afterward, there may be some throbbing.