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 General Gynecology

Cervical dysplasia

Cervical dysplasia

Female reproductive anatomy
Female reproductive anatomy
Cervical neoplasia
Cervical neoplasia
Uterus
Uterus
Cervical dysplasia - series
Cervical dysplasia - series

Definition:

Cervical dysplasia is the abnormal growth of cells on the surface of the cervix. Although this is not cancer, this is considered a pre-cancerous condition. Depending on the extent of changes, the condition is further categorized as:

  • CIN I -- mild dysplasia (a few cells are abnormal)
  • CIN II -- moderate to marked dysplasia
  • CIN III -- severe dysplasia to carcinoma-in-situ (cancer confined to the surface layer of the cervix)
Alternative Names:
Cervical intraepithelial neoplasia (CIN); Precancerous changes of the cervix
Causes, incidence, and risk factors:

Less than 5% of all Pap smear test results find cervical dysplasia. While the cause is unknown, a number of risk factors have been identified. Most cases occur in women aged 25 to 35.

Other risk factors include:

  • Multiple sexual partners
  • Starting sexual activity before age 18
  • Having children before age 16
  • DES exposure
  • Having had sexually transmitted diseases, especially HPV (genital warts) or HIV infection
Symptoms:

There are usually no symptoms.

Signs and tests:

A pelvic examination is usually normal.

The following tests may indicate cervical dysplasia:

  • Pap smear showing mild, moderate, marked, or severe dysplasia.
  • Colposcopy revealing "white epithelium." These are mosaic-like patterns on the surface of the cervix, caused by changes in the surface blood vessels.
  • Colposcopy-directed biopsy to confirm dysplasia and the extent of cervical involvement.
  • Endocervical curettage to rule out involvement of the cervical canal.
  • Cone biopsy may be necessary to rule out invasive cancer.

Review Date: 5/6/2007
Reviewed By: Rachel A. Lewis, MD, FAAP, Columbia University Pediatric Faculty Practice, New York, NY. Review provided by VeriMed Healthcare Network.

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