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 Leukemia

Hairy cell leukemia

Hairy cell leukemia

Bone marrow aspiration
Bone marrow aspiration
Auer rods
Auer rods
Hairy cell leukemia - microscopic view
Hairy cell leukemia - microscopic view
Formed elements of blood
Formed elements of blood
Enlarged spleen
Enlarged spleen

Definition:

Hairy cell leukemia (HCL) is a rare cancer of the blood. It affects B cells, a type of white blood cell (lymphocyte).

Alternative Names:
Leukemic reticuloendotheliosis; HCL; Leukemia - hairy cell
Causes, incidence, and risk factors:

HCL is caused by the abnormal growth of B cells. The cells can look "hairy" under the microscope because they have fine projections coming from their surface.

HCL can lead to low numbers of normal blood cells.

The cause of this disease is unknown. It affects men more often than women. The average age of onset is 55. Hairy cell leukemia is rare.

Symptoms:
  • Weakness
  • Fatigue
  • Weight loss
  • Easy bruising or bleeding
  • Recurrent infections and fevers
  • Excessive sweating (especially at night)
  • Swollen lymph glands
  • Feeling full after eating only a small amount (early satiety)
Signs and tests:

During a physical exam, the doctor may be able to feel a swollen spleen or liver. An abdominal CT scan may be done to confirm this swelling.

A complete blood count shows low levels of white and red blood cells, as well as platelets.

Blood tests and a bone marrow biopsy can detect hairy cells. A test called TRAP can confirm the cancer diagnosis.


Review Date: 4/27/2007
Reviewed By: Rita Nanda, M.D., Department of Medicine, Section of Hematology/Oncology, University of Chicago Medical Center, Chicago, IL. Review provided byVeriMed Healthcare Network.

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