List of Topics Print This Page

 Hematology

Multiple myeloma

Multiple myeloma

Cryoglobulinemia - of the fingers
Cryoglobulinemia - of the fingers
Immune system structures
Immune system structures
Antibodies
Antibodies

Definition:

Multiple myeloma is a cancer of the plasma cells in bone marrow.

Alternative Names:
Plasma cell dyscrasia; Plasma cell myeloma; Malignant plasmacytoma; Plasmacytoma of bone; Myeloma - multiple
Causes, incidence, and risk factors:

Plasma cells help the body's immune system fight disease. Multiple myeloma occurs when plasma cells grow out of control. Excessive plasma cells can form a tumor in the bone marrow called a myeloma. Many tumors are called multiple myeloma.

The growth of the excess plasma cells interferes with the production of red blood cells, white blood cells, and platelets. This causes anemia and makes a person more likely to get infections and have abnormal bleeding.

As the cancer cells grow in the bone marrow, they cause pain and destruction of the bones. If the bones in the spine are affected, it can put pressure on the nerves, resulting in numbness or paralysis.

Renal failure (kidney failure) is a frequent complication.

Multiple myeloma mainly affects older adults. A history of radiation therapy raises your risk for this type of cancer.

Symptoms:
  • Bone or back pain
  • Unexplained fractures
  • Bleeding problems
  • Increased susceptibility to infection
  • Symptoms of anemia (such as tiredness, shortness of breath, and fatigue)
Signs and tests:

Blood tests can help diagnose this disease.

  • A newer blood test called the Freelite diagnostic assay can be used to diagnose and monitor multiple myeloma.
  • A blood chemistry test shows increased levels of calcium, total protein, and abnormal kidney function.
  • A complete blood count (CBC) reveals low hematocrit (anemia) and a low number of red and white blood cells and platelets.
  • Serum protein electrophoresis, a test to measure various types of protein part of the blood, is abnormal.

Bone x-rays show fractures or hollowed out areas of bone. If your doctor suspects this type of cancer, a bone marrow biopsy will be performed.

This disease may also alter the results of the following tests:

Review Date: 9/20/2006
Reviewed By: Corey Cutler, MD, MPH, FRCP(C), Assistant Professor of Medicine, Harvard Medical School; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA. Review provided by VeriMed Healthcare Network.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright 2002 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

  View History
 Multiple myeloma

   
   

 

About UPHS   Contact Us   Site Map   Privacy Statement   Legal Disclaimer   Terms of Use

The University of Pennsylvania Health System, Philadelphia, PA 1-800-789-PENN © 2008, The Trustees of the University of Pennsylvania