Acute pancreatitis is an inflammation (irritation and swelling) of the pancreas. The pancreas is a long gland, located behind the stomach, that secretes digestive enzymes and the hormones insulin and glucagon.

The chief causes of acute pancreatitis in adults are gallstones, other gallbladder (biliary) disease, and alcohol use. Other causes include:

• Viral infection (mumps, coxsackie B, mycoplasma pneumonia, and campylobacter)
• Traumatic injury
• Pancreatic surgical procedures
• Common bile duct surgical procedures
• Certain medications (especially estrogens, corticosteroids, thiazide diuretics, and azathioprine)

Acute pancreatitis may also be caused by an abnormal structure of the pancreas, genetic factors (hereditary pancreatitis), high lipid levels in the blood (hypertriglyceridemia), and complications of cystic fibrosis.

The mechanism that causes pancreatitis is not well known. It is thought that enzymes normally secreted by the pancreas in an inactive form become activated inside the pancreas and start to digest the pancreatic tissue. This process is called autodigestion and causes swelling, hemorrhage, and damage to the blood vessels.

The disease affects men more often than women. Alcohol abuse is an important risk factor.

In children, this disorder may be associated with:

• Abdominal trauma
• Cystic fibrosis
• Hemolytic uremic syndrome
• Kawasaki disease
• Mumps
• Reye syndrome
• Various viral illnesses
• Some medications

• Abdominal pain that is greatest in the upper abdomen (upper left quadrant or upper middle of the abdomen)
  • Is persistent or chronic
  • May be worse lying flat on the back
  • May radiate to the back or below the left shoulder blade
  • May be worse after eating or drinking (occurs within minutes following meals), especially foods with a high fat content
  • May be worse after drinking alcohol
• Nausea and vomiting
• Sweating
• Anxiety
• Fever
• Mild jaundice

Additional symptoms that may be associated with this disease:

• Swollen abdomen
• Gaseous abdominal fullness
• Abdominal indigestion
• Hiccups
• Skin rash or lesion
• Clay-colored stools

General examination may show fever, low blood pressure, rapid heart rate or rapid respiratory rate.

Tests that show release of pancreatic enzymes:

• Elevated serum amylase
• Elevated urine amylase
• Elevated serum lipase

Test that show inflammation of the pancreas:

• Abdominal CT scan
• Abdominal ultrasound
• Abdominal MRI

In other blood tests results:

• CBC shows an elevated WBC coun.
• A glucose test may show elevated levels.
• Serum calcium may be decreased.