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 Liver Disease

Drug-induced hepatitis

Drug-induced hepatitis

Digestive system
Digestive system
Hepatomegaly
Hepatomegaly

Definition:

Drug-induced hepatitis is inflammation of the liver that may occur when you take certain medications.

See also:

Alternative Names:
Toxic hepatitis
Causes, incidence, and risk factors:

The liver helps the body break down certain drugs. However, the way it does so differs from person to person. Therefore, may different drugs can cause drug-induced hepatitis.

Painkillers and fever reducers that contain acetaminophen are a common cause of liver inflammation. These medications can damage the liver when taken in doses that are not much greater than the recommended therapeutic dose.

Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen may also cause drug-induced hepatitis.

Other drugs that can lead to liver inflammation include:

  • Amiodarone
  • Anabolic steroids
  • Birth control pills
  • Chlopromazine
  • Erythromycin
  • Halothane
  • Methyldopa
  • Isoniazid (used to treat tuberculosis)
  • Methotrexate
  • Statins
Symptoms:
Signs and tests:

Blood tests will be done to check liver function. Liver enzymes may be increased.

A physical exam may reveal an enlarged liver and abdominal tenderness in the right upper part of the belly area.


Review Date: 11/13/2007
Reviewed By: Christian Stone, M.D., Division of Gastroenterology, Washington University in St. Louis School of Medicine, St. Louis, MO. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright 2002 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

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