List of Topics Print This Page

 Interstitial Lung Disease (ILD)

Diffuse interstitial lung disease

Diffuse interstitial lung disease

Clubbing
Clubbing
Coal workers pneumoconiosis - stage II
Coal workers pneumoconiosis - stage II
Coal workers pneumoconiosis - stage II #2
Coal workers pneumoconiosis - stage II #2
Coal workers pneumoconiosis, complicated
Coal workers pneumoconiosis, complicated
Respiratory system
Respiratory system

Definition:

Diffuse interstitial lung disease refers to a group of lung disorders in which the deep lung tissues become swollen and scarred.

Alternative Names:
Diffuse parenchymal lung disease; Alveolitis; Cryptogenic fibrosing alveolitis (CFA); Idiopathic pulmonary pneumonitis (IPP)
Causes, incidence, and risk factors:

Interstitial lung diseases (ILD) are caused by swelling and scarring of the air sacs (alveoli) and their supporting structures (the interstitium). This leads to reduced levels of oxygen in the blood.

The interstitial lung diseases can be broken down into two large groups:

  • Those that have no known cause (idiopathic ILD)
  • Those with an identifiable cause

One recent system further divides idiopathic ILD into the following three groups:

  • Idiopathic pulmonary fibrosis/usual interstitial pneumonitis (IPF/UIP)
  • Non-specific interstitial pneumonitis (NSIP)
  • Acute interstitial pneumonitis (AIP)

There are dozens of different causes of ILD. Many occupational substances can cause ILD, including:

  • Asbestos
  • Coal dust
  • Cotton dust
  • Sand (silica) dust

Persons who are heavily exposed to known causes of occupational lung disease in the workplace are usually routinely screened for lung disease. This can include coal miners, sand-blasters, ship workers, and others.

Occasionally, bird keeping or bathing in hot tubs may cause some forms of ILD.

The following diseases can cause ILD:

Certain medications (such as bleomycin, amiodarone, and methotrexate) may also cause ILD.

Cigarette smoking may increase the risk of developing some forms of ILD and may cause the disease to be more severe.

Symptoms:
  • Abnormal enlargement of the base of the fingernails (clubbing)
  • Blue color of the lips, skin, or fingernails due to low blood oxygen levels (cyanosis)
  • Decreased tolerance for activity
  • Dry cough
  • Rapid breathing
  • Shortness of breath at rest or while active
Signs and tests:

The health care provider will perform a physical exam. Dry, crackling breath sounds may be heard when listening to the chest with a stethoscope. The health care provider may notice nasal flaring.

The following tests may be done:


Review Date: 1/18/2008
Reviewed By: Andrew Schriber, MD, FCCP, Specialist in Pulmonary, Critical Care, and Sleep Medicine, Virtua Memorial Hospital, Mount Holly, New Jersey. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright 2002 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

  View History
 Diffuse interstitial lung disease

   
   

 

About UPHS   Contact Us   Site Map   Privacy Statement   Legal Disclaimer   Terms of Use

The University of Pennsylvania Health System, Philadelphia, PA 1-800-789-PENN © 2008, The Trustees of the University of Pennsylvania