The Center for Bloodless Medicine & Surgery at Pennsylvania Hospital
 

Fall 2004

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Alternatives to Blood Transfusions

Fall 2004

Acute normovolemic hemodilution (ANH) and preoperative autologous blood donation (PABD) are two techniques used for patients who refuse donor blood transfusions, due to safety concerns or personal reasons. Acute normovolemic hemodilution, or ANH, is a technique used in bloodless surgery, which significantly reduces the amount of red blood cells lost during surgery. Prior to surgery, an IV is started in the patient's arm and blood is slowly drained inside a closed system. A combination of water and minerals replaces the blood, which helps to maintain the patient's vital sign stability.

During the surgery, some blood is lost; however, since the blood has been diluted, it contains fewer cells and more liquid. The anesthesiologist is then able to give back whole, fresh blood to the patient. The blood never loses contact with the patient's own circulatory system, so there is no chance of clerical error, which can occur with preoperative autologous blood donation.

Another alternative to donor blood transfusions, preoperative autologous blood donation (PABD), involves the collection and reinfusion of the patient's own blood. Two to three weeks prior to surgery, patients donate two to four units of their own blood, which is then given back to them during or after surgery.

People who refuse blood transfusions for religious or personal reasons should note that preoperative autologous blood donation involves storing the blood. In some cases, storage of one's own blood for anticipated reinfusion has lead to clerical errors and resulted in the transfusion of someone else's blood. Also, PABD cannot be performed in patients undergoing non-elective surgical procedures.

Why is ANH effective?
The ANH method reduces and eliminates the need for a blood transfusion by decreasing the amount of red blood cells lost during surgery. Since a blood transfusion is usually not required, there is no risk of an allergic reaction or disease transmission. With PABD, patients who donate their own blood weeks before surgery are doing so with lower blood counts.

These patients would be more likely to need a transfusion sooner than someone who did not donate their own blood. In conclusion, ANH is less costly and equally as effective as PABD, in addition to being a more convenient method for the patient.

 


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